Bouyei minority Shitou village, west Guizhou (near Longgong caves), China. | t = | p = Guìzhōu | psp = Kweichow | gr = Gueyjou | w = Kuei4-chou1 | myr = Gwèijōu | mi = | bpmf = ㄍㄨㄟˋ   ㄓㄡ | j = Gwai3zau1 | y = Gwaijàu ''or'' Gwaijāu | ci = ''or'' | poj = Kùi-chiu | wuu = Kwae-tseu | order = st | showflag = p | c = | altname = | lang1 = Zhuang | lang1_content = Gveicouh
贵州 | lang2 = Yi | lang2_content = ꇭꍏ | tib = ཀུའེ་ཀྲོའུ་ | wylie = ku'e kro'u }}

Guizhou (; alternately Kweichow) is a landlocked province in the southwest region of the People's Republic of China. Its capital and largest city is Guiyang, in the center of the province. Guizhou borders the autonomous region of Guangxi to the south, Yunnan to the west, Sichuan to the northwest, the municipality of Chongqing to the north, and Hunan to the east. The population of Guizhou stands at 38.5 million, ranking 18th among the provinces in China.

The Dian Kingdom, which inhabited the present-day area of Guizhou, was annexed by the Han dynasty in 106 BC. Guizhou was formally made a province in 1413 during the Ming dynasty. After the overthrow of the Qing in 1911 and following the Chinese Civil War, the Communist Party of China took refuge in Guizhou during the Long March between 1934 and 1935. After the establishment of the People's Republic of China, Mao Zedong promoted the relocation of heavy industry into inland provinces such as Guizhou, to better protect them from potential foreign attacks.

Guizhou is rich in natural, cultural and environmental resources. Its natural industry includes timber and forestry, and the energy and mining industries constitute an important part of its economy. Notwithstanding, Guizhou is considered a relatively undeveloped province, with the fourth-lowest GDP per capita in China as of 2020. However, it is also one of China's fastest-growing economies. The Chinese government is looking to develop Guizhou as a data hub.

Guizhou is a mountainous province, with its higher altitudes in the west and centre. It lies at the eastern end of the Yungui Plateau. Demographically, it is one of China's most diverse provinces. Minority groups account for more than 37% of the population, including sizable populations of the Miao, Bouyei, Dong, Tujia and Yi peoples, all of whom speak languages distinct from Chinese. The main language spoken in Guizhou is Southwestern Mandarin, a variety of Mandarin. Provided by Wikipedia